Epoxyquinomicins A, B, C and D, new antibiotics from Amycolatopsis. III. Physico-chemical properties and structure determination.
نویسندگان
چکیده
The structures of epoxyquinomicins A (1), B (2), C (3) and D (4) were determined by spectroscopic studies. Compound 1 was determined to be (5R,6S)-2-(3-chloro-2-hydroxybenzoylamino)-5-hydroxymethyl-5,6-epo xy- 2-cyclohexene-1,4-dione. Compound 2 was revealed to be the dechlorinated derivative of 1. Compounds 3 and 4 were determined to be the reduced derivative of 2 and 1, respectively.
منابع مشابه
Epoxyquinomicins A and B, new antibiotics from Amycolatopsis.
Sir: In the course of a screening program for new antibiotics, we isolated newantibiotics, epoxyquinomicins A (1) and B (2) from the culture broth of Amycolatopsis sp. MK299-95F4, which was isolated from a soil sample collected at Sendai city, Miyagi Prefecture, Japan. In this paper we report the production, isolation, physico-chemical properties, biological properties and structures of 1 and 2...
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The anti-arthritic effects of epoxyquinomicins on type II collagen-induced arthritis in DBA/1J mice were examined. Prophylactic treatment with epoxyquinomicins A, B, C and D (1-4 mg/kg) had potent inhibitory effects on type II collagen-induced arthritis. In contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), epoxyquinomicin C (1-30 mg/kg) had neither an anti-inflammatory effect on carrag...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 50 11 شماره
صفحات -
تاریخ انتشار 1997